Welcome to the Immune Dictionary Portal!

The Immune Dictionary is a compendium of single-cell transcriptomic profiles of over 17 cell types in response to each of 86 cytokines.

More Details on the Publication:
Cui, A. et al., Dictionary of immune responses to cytokines at single-cell resolution. Nature. https://doi.org/10.1038/s41586-023-06816-9 (2023)

Dictionary of immune responses to cytokines reference map

Immune Response Enrichment Analysis (IREA)

IREA is the companion software for the Immune Dictionary. It assesses cytokine activities, immune cell polarization, and cell-cell communication from user transcriptomic data.

IREA workflow and output summary

Data Browser

Interactively inspect cytokine-induced gene expression via violin plots, box plots, UMAPs, bar graphs, and heatmaps.

IREA Software

Infer cytokine response and cell polarization from your own gene inputs.

Reference Cards

Browse PDF summaries of cytokine response patterns and immune states.

Download

Download Seurat objects and cytokine signature Excel tables.

Instructions

Get guidance for each tab and analysis mode in the portal.